Aquaculture has grown consistently over the last decade and aqua species production will continue to increase, as a result of growing demand for seafood (Huntington and Hasan, 2009). However, aquaculture has to face important challenges in terms of health management and environmental impact like intensive fish farming, increase in water temperature due to global warming, world sea metal pollution, and pathogen infections (Cochrane et al., 2009). All these challenges induce oxidative stress in fish that could depress growth performance and impact the anti-oxidative ability (Slaninova et al., 2009). There is a growing intertest in use bioactive compounds of plant extracts and organic acids as feed additives, because of their antimicrobial power as well as their potential positive effect on immune defense mechanisms, but little is known about their potential against oxidative stress. The aim of this study was to assess the effect of thymol and sorbic acid on PHLC-1 hepatocytes cell line during a H2 O2-induced oxidative stress. The PLHC-1 (Poeciliopsis lucida hepatocellular carcinoma) cell line was used in this study since it is a recognized in vitro model to study the hepatic metabolism in fish.
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Discover More: Esteban et al. (2019). Aquaculture Europe 2019