The objective of this study was to investigate the effi cacy of bioactive compounds in the inhibition and control of Salmonella typhimurium ATCC® 6994™ in vitro. The antimicrobial activity of organic acids (citric acid, sorbic acid, benzoic acid, butyric acid, and hexanoic acid) and nature identical compounds (thymol, vanillin, carvacrol, and eugenol) has been evaluated by a microdilution MIC test. All the nature identical compounds were effective in inhibiting bacterial growth and in particular thymol and carvacrol showed the lowest MIC compared to all the substances tested (1.87 mM). Among organic acids, sorbic acid, benzoic acid and hexanoic acid had a MIC of 100 mM. Thymol, carvacrol and sorbic acid were selected for a time-kill study, from which emerged the bactericidal action of the two nature identical compounds and the bacteriostatic action of sorbic acid. The results of this study indicate that these bioactive compounds can therefore be used as feed additives to control Salmonella typhimurium in pigs.
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Discover More: Giovagnoni et al. (2021). XLVI meeting annuale Società Italiana di Patologia ed Allevamento dei Suini (SIPAS)