A Blend Of Thymol And Organic Acids Can Support The Antimicrobial Activity Of Conventional Antibiotics Against Streptococcus Suis

The objective of this study was to assess the antimicrobial activity of conventional antibiotics, organic acids and nature identical compounds against five field strains of Streptococcus suis, and then to examine whether the combination of these substances could support the action of not effective antibiotics against one of the most common serotypes worldwide. A minimal inhibitory concentration (MIC) test was first performed using the microdilution method following the CLSI guidelines. Tetracycline, neomycin, tylosin, and tiamulin showed variable sensitivity patterns and the higher MIC values. Among the tested organic acids and nature identical compounds, citric acid, dodecanoic acid, and thymol had the most marked inhibitory effect. Therefore, these compounds were combined in order to create a prototype, used to increase the efficacy of the abovementioned antibiotics. The combination was tested against strain 703 (serotype 2) and supported the action of the four conventional antibiotics, inhibiting bacterial growth between 74 and 92% overall. The mixture of citric acid, dodecanoic acid, and thymol can thus be used to counteract the antibiotic resistance issue.

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Discover More: Giovagnoni et al. (2023). XLVIII meeting annuale Società Italiana di Patologia ed Allevamento dei Suini (SIPAS)